Genetic fertility screening is a type of personalized genetic testing that determines genetic causes of infertility in males and females. Known genetic causes for infertility include chromosomal abnormalities and genetic mutations. Genetic fertility screening can improve the chances of reproductive & IVF success and help provide personalized treatment plans.
It has been estimated that 50% of infertility cases could have a genetic factor. Fertility genetic screening is the missing puzzle piece of the infertility puzzle. Evolve genetic fertility screens can improve IVF success rates and provide valuable knowledge and insight to you and your healthcare provider regarding your fertility health.
Any female with a personal history of infertility, an elevated follicle-stimulating hormone (FSH) level before age 40 (without a known cause), or a family history of ovarian failure should have fertility screening.
Any male with personal history of infertility, abnormal sperm parameters on semen analysis, or a family history of male infertility should have fertility screening.
Chromosome analysis (also known as karyotyping) is a test that evaluates the number and structure of a person’s chromosomes in order to detect abnormalities.
It is included in both Evolve’s Male and Female fertility screen as a key component to infertility testing since structural chromosomal abnormalities are the most common genetic cause of infertility. An infertility genetic screen in incomplete without including a complete chromosome analysis.
There is a natural decline in ovarian function as a women ages. However, many women have premature aging of the ovaries and this premature aging can occur in as early as a women’s early to mid-20’s. With premature ovarian aging (POA) a women will have a decreased fertility due to a decrease low or sub-optimal number of eggs and poor quality of eggs. Smaller number of lower-quality eggs reduce women’s fertility in two ways: they make it more difficult to get pregnant, and once pregnant, miscarriage are more likely to occur.
Premature Ovarian Failure occurs when ovaries prematurely stop making eggs. Normally this occurs in a women’s 40 during menopause.
Genetic abnormalities are a significant risk factor for developing POA/POF. It has been estimated that 10-30% of POF cases are due to a genetic abnormality.
The FMR1 (Fragile X Mental Retardation 1) gene is located on the X chromosome. It is of importance to women because not only does the FMR1 premutation put women at significant risk for premature ovarian failure and other fertility issues but are also at an increased risk of having a child with Fragile X syndrome.
Fragile X syndrome is a genetic disorder that causes intellectual disability and various physical and behavioral abnormalities. It is the most common cause of inherited autism in children.
Therefore, the FMR1 premuation puts millions of women at risk of infertility and most have never even heard of it. 1 in 150 women are estimated to be carriers of the FMR1 premutation.
The Evolve Female Fertility Screen and the Evolve POF screen both analyze the FMR1 gene. Evolve’s screens will detect ALL CASES of FMR1 (Fragile X) premutation.
Currently clinics and healthcare providers will only look at genetic factors after multiple IVF or fertility failures and many will not take genetics into consideration. By having this information at the onset of your fertility journey you and your healthcare provider will have the information needed to make better and more informed decisions for better outcomes.
EvolveGene® is the leader in fertility genetic screening and offers the most reliable and comprehensive male and female genetic screens on the market.
The American Congress of Obstetricians and Gynecologists (ACOG) and the American Society for Reproductive Medicine (ASRM) both have policies and recommendations for genetic fertility screening in males and females.
Evolve Fertility Screens are most useful when offered to patients before they undergo IVF or other fertility treatments. These screens should be offered as part of the initial diagnostic evaluation of the patient in a Pre-IVF consultation. Evolve Fertility Screens will reveal genetic contributions to infertility that cannot be detected by a physical exam of the patient.
Your genetics does not change with age therefore Evolve genetic fertility screens can be taken at any age. However, they are recommended as pre-conception or- pre-IVF screens for individuals of reproductive age.
The Evolve POF screen can be taken as early as a women’s early 20’s to determine if she is at risk of developing premature ovarian aging or failure. However, the screen can be taken at any age, but is of most use to women of reproductive age.
Yes, at EvolveGene® we work with your healthcare provider to order a fertility screening kit for you.
A simple blood test is needed for fertility screening. EvolveGene® provides convenient sample collection kits for you and your healthcare provider to use.
Our results for fertility screening are available three-four weeks after your sample has been received by our laboratory.
When your results are ready, you will receive an email alert. Patient reports will be made available for you and your healthcare provider to review. A Board-Certified Genetic Counselor will also be available to you at no extra charge to answer any of your questions and review your results.
Infertility affects 1 in 6 couples worldwide and the number of couples going through IVF has increased drastically in the last 10 years. Your genetic makeup plays a significant role in your fertility and it only makes sense that a complete genetic workup should be part of the standard fertility patient evaluation.
Genetic fertility screening can improve the chances of reproductive & IVF success and help provide personalized treatment plans.
By understanding if there is a genetic component to you and/or your partner’s infertility you and your healthcare provider will have answers to questions that previously would have gone unanswered. Evolve Fertility screen results will help enable clinicians to proactively devise appropriate management guidelines and effective treatments for patients before experiencing costly and time consuming setbacks from failed fertility treatments.
EvolveGene® offers distinct male and female fertility screens, bringing actionable results to help improve your chances of reproductive success.
Male Fertility Screen
Female Fertility Screen
Premature Ovarian Failure Screen
EvolveGene® is built on 25+ years of expertise in the field of human reproductive medicine with a scientific team of world leading embryologists, geneticists and fertility experts. Through collaboration with our network of leading fertility and IVF clinics; EvolveGene® is committed to providing innovative, reliable, and comprehensive genetic fertility screening.
The Evolve Female Fertility Screen combines three testing methodologies in one complete screening package to save you both time and money.
This screen includes FMR1 (Fragile X) trinucleotide repeat analysis, Next Generation Sequencing (NGS) of genes highly associated with female infertility in addition to a complete chromosome analysis.
The Evolve Male Fertility Screen combines three testing methodologies in one complete screening package to save you both time and money.
This screen includes Y chromosome deletion analysis, NGS of genes highly associated with male infertility in addition to a complete chromosome analysis.
NGS for Evolve Fertility Screen gene panels has accurate detection rates with >99% analytical sensitivity and false negative rates of <1%. In addition, all cases of FMR1 premutation expansion mutations will be detected by this testing for females; and >99% of Y chromosome deletions will be detected in males.
Can the Evolve Fertility Screens be used to detect mosaicism of chromosome disorders? For example, in the case of a chromosomal disorder such as Klinefelter syndrome, will it be possible to detect if the individual is mosaic?
The Evolve Male and Female Fertility Screens can be used to detect mosaicism of chromosome disorders, such as Klinefelter syndrome, with a detection rate and sensitivity of ~99%.
On average the lowest percentage of mosaicism that the Evolve Male and Female Fertility Screens can detect is 6%.
Evolve POF screen will help you and your healthcare provider if you are at risk for premature decline of your ovarian function.
The Evolve POF screen includes mutation analysis of genes associated with low or poor amounts of ovarian eggs + FMR1 (Fragile X) trinucleotide repeat analysis.
The Evolve POF Screen is a highly specialized and advanced genetic screen for women with a family history of POF or features of POF. The POF Screen includes accurate detection for 100% of CGG repeat expansions that can cause POF and Fragile X Syndrome and NGS technology with >99% analytical sensitivity and false negative rates of <1% for the remaining genes on the panel.
Evolve Fertility Screens for males and females assess the chromosome status of the parents and do not replace the need for a polar body biopsy which assesses the chromosome status of an embryo. Although the chromosome status of the parents may have some influence to an aneuploidy oocyte, chromosome aneuploidy may still arise during the initial stages of the development of the 1st and 2nd polar bodies. Evolve Fertility Screens are best suited for individuals who want to determine genetic factors that may be impacting their fertility or potentially passing on a genetic disease before IVF is performed.
Yes, because the Evolve Female Fertility Screen looks for different genetic disorders than the Evolve EarlyPregnancy™ Screen each test is important to perform independently. Evolve Female Fertility Screen assesses a female’s personal genetic factors that can impact fertility. Evolve EarlyPregnany™ Screen detects whether chromosome genetic disorders, such as Down syndrome, that are suspected during a pregnancy. Consider having the Evolve Female Fertility Screen before a pregnancy either as a pre-IVF or pre-conception tool, or the Evolve EarlyPregnancy™ Screen during a pregnancy as a prenatal test.
Evolve Genetic Fertility Screens are designed specifically for those individuals with a personal or family history of fertility issues to assess their genetic risks for infertility. Evolve FamilyReady™ Carrier Screen is designed for both males and females to determine if either are carriers of genetic disorders that could impact their children. Thus, to determine genetic causes of infertility, use the Evolve Genetic Fertility Screens; when determining the risk of a genetic disorder in children, use the Evolve FamilyReady™ Carrier Screen. Results from either the Evolve Genetic Fertility Screens and the Evolve FamilyReady™ Carrier Screen can impact reproductive management options including pre-IVF care to improve the chances of a successful pregnancy.
Yes all three Evolve Fertility Screens (Male, Female, POF) include complimentary pre- and post- screen genetic counseling with a Board Certified Genetic Counselor if requested by the patient or healthcare provider.
Evolve Genetic Carrier Screens can be ordered based on our catalog codes below.
Evolve FamilyReady™ Carrier Screen………….Cat #CFRS
Evolve Ashkenazi Jewish Carrier Screen…….Cat #CAJS
Evolve ACOG/ACMG Carrier Screen…………Cat #ACOG
Evolve Genetic NIPT Screens can be ordered based on our catalog code below.
Evolve EarlyPregnancy™ Screen………………Cat #NIPT
Evolve Genetic Fertility Screens can be ordered based on our catalog codes below.
Evolve Male Fertility Screen…………………..Cat #MFGS
Evolve Female Fertility Screen………………..Cat #FFGS
Evolve Premature Ovarian Failure Screen…..Cat #FPOF
The World Health Organization created the International Classification of Disease, tenth revision (ICD-10) as a system of coding for medical records including diseases, symptoms, and abnormal findings. These standards are accepted throughout the healthcare industry for a diagnostic coding system.
CPT codes are identifying codes given to a medical/diagnostic procedure that describes the services rendered. These codes are used by hospitals, physicians, and healthcare providers to communicate procedures or tests ordered to your insurance carrier.
FamilyReady™ Carrier Screening
81161 x1, 81200 x1, 81205 x1, 81209 x1, 81220 x1, 81222 x1, 81243 x1,
81251 x1, 81304 x1, 81330 x1, 81332 x1, 81400 x1, 81401 x1, 81404 x1
Evolve Female Fertility Screens
Evolve Male Fertility Screens
81220 x1, 81224 x1, 81403 x1, 81479 x1
Evolve EarlyPregnancy™ Screen
Please contact us at support@EvolveGene.com or Chat at EvolveGene.com if you have questions regarding billing.
After a screening kit is ordered, a healthcare provider submits a requisition form to Evolve and a patient registers the kit through our online portal on EvolveGene.com prior to sample collection.
No, each Evolve Screen is a clinical laboratory test that requires a healthcare provider’s approval prior to screening under current laws and regulations.
Yes, you can order multiple screening kits for your clinics. A patient could then purchase a kit directly in clinic when needed.
To send sample kits back to Evolve, please enclose kit inside the prepaid envelope to ensure free shipping to our laboratory.
Evolve genetic consultations ensure you have access to expert and compassionate services. During consultations, your results will be explained in the context of your fertility, family, and medical history. Genetic counselors see to it that you can facilitate reproductive health decisions based on your results.
Our team of trained and board certified genetic counselors are on hand to make certain genetic screening is as understandable as possible. Genetic consultation services are available at no additional cost for both healthcare providers and patients. Please contact us at specialists@EvolveGene.com or Chat at EvolveGene.com to schedule a genetic consultation.
Yes, at Evolve our complimentary genetic counseling is accessible to everyone by working with certified interpreters if a language other than English is spoken.
To find out if Evolve Genetic Screens are available in your country, please contact us at support@EvolveGene.com or Chat at EvolveGene.com.
If an interpreter is required for a consultation, please indicate the requested language along with the your international phone number (including country code) when scheduling a genetic consultation.
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