An Overview of the Effects of Age on Fertility in Women

by Don Rieger, PhD

Vice Preisdent, Research and Development, LifeGlobal LLC

For a variety of social and economic reasons, women (and couples) are putting off having babies until they are in their mid-thirties, or later. This trend is common to most industrialized countries. In the United States, the average maternal age at first birth increased from 21.4 to 24.9 years of age from 1970 to 2000. Overall, birth rates in the United States decreased from 1970 to 1980, but since then, the birth rates for women over 30 years of age have increased significantly.

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Is there a small RNA fingerprint of embryo quality and health in spent IVF media?

by Allison Tscherner, Leanne Stalker, and Jonathan LaMarre

With improved technologies and enhanced understanding of cellular pathways that influence the success of failure of IVF procedures, there is an increasing demand for techniques to rapidly and non-invasively assess the health and developmental competence of individual embryos in clinical settings. These demands are further fueled by increasing age in those seeking ART to fulfill their reproductive aspirations (where the risk of embryo loss and genetic abnormalities is higher) and increasing demands by healthcare funders and regulators to perform single-embryo transfer in order to minimize potential complications associated with multiple gestation pregnancies.

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